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5-Formyl Tetrahydrofolate

800 mcg from Calcium Folinate

An Natural, Active, Coenzyme Form of Folate

Folinic Acid

FOLINIC ACID, which also is known as 5-formyl tetrahydrofolate, is one active form in a group of vitamins known as folates. In contrast to folic acid, a synthetic form of folate, folinic acid is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. Folinic acid in the body can be converted into any of the other active forms of folate.

Folinic Acid contains 800 mcg of folinic acid from a very pure form of calcium folinate. It is contained in a small gelatin capsule only with microcrystalline cellulose (filler) and silica (flow agent). It contains no magnesium stearate.


Folate coenzymes (including Folinic Acid and L-5-MTHFare responsible for the following important metabolic functions and benefits: 1) Formation of purines and pyrimidines, which in turn are needed for synthesis of the nucleic acids DNA and RNA. This is especially important during fetal development in the first trimester in preventing birth defects, such as neural tube defects, 2) Formation of heme, the iron-containing protein in Folinic Acidhemoglobin, 3) Interconversion of the 3-carbon amino acid serine from the 2-carbon amino acid glycine, 4) Formation of the amino acids tyrosine from phenylalanine and glutamic acid from histidine, 5) Formation of the amino acid methionine from homocysteine (Vitamin B12 as methylcobalamin also is needed for this conversion). In the reconversion of homocysteine to methionine the body uses the methionine to make the important amino acid s-adenosylmethionine (SAMe) which is known to be helpful in cases of depression, 6) Synthesis of choline from ethanolamine, 7) Formation and maturation of red and white blood cells, and 8) Conversion of nicotinamide to N’-methylnicotinamide.

Numerous drugs are known to inhibit the body’s ability to utilize folate, including: 1) aspirin, 2) cholesterol lowering drugs, 3) oral birth control pills, 4) antacids, and 5) methotrexate when used for rheumatoid arthritis. When taking these drugs (and many others) it is recommended that you take 800 mcg daily of folate, preferably as folinic acid (or 5-MTHF). When taking folate it is recommended that you take adequate amounts of Vitamin B12 as methylcobalamin. (Please note that folate supplementation may interfere with anticonvulsant drugs.)

COMPOSITION: One capsule contains the following amount of the Daily Value:

Folinic Acid (from calcium folinate) 800 mcg 200%

DIRECTIONS: As a dietary supplement take one capsule daily with food, or as directed by a health care professional.

INGREDIENTS: FOLINIC ACID contains only the highest-quality microcrystalline cellulose, gelatin (capsule), silica, and calcium folinate.

FOLINIC ACID does not contain wheat, rye, oats, corn, barley, gluten, soy, egg, dairy, yeast, GMOs, sucrose, fructose, wax, preservatives, colorings, or artificial flavorings.




These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.