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A ‘Hank and Brian’s™ exclusive only from HPDI 

Our Most Complete Essential Fatty Acid Formula

Balanced Omega-3 and Omega-6 Essential Fats plus Mixed Tocopherols/Tocotrienols

Essential Fats Plus E (180 softgels)

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Essential Fats Plus E

ESSENTIAL FATS PLUS E is HPDI’s custom-designed “top-of-the-line” fatty acid formula, providing optimal levels (and ratios) of essential fats required for human health. Essential fats have proven highly beneficial for cardiovascular health, brain and cerebral function, cell membrane health, anti-inflammatory processes, and many other critical functions in the human body (see below).

The formula contains Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) (important essential omega-3 fatty acids), Gamma Linolenic Acid (GLA) (an important essential omega-6 fatty acid), and mixed Tocotrienols and Tocopherols (Vitamin E).

ESSENTIAL FATS PLUS E contains EPA and DHA in their natural form as triglycerides derived from marine lipids (using patented flash molecular distillation) and GLA from cold-pressed borage seed oil. Every batch of fish oil contained in ESSENTIAL FATS PLUS E is tested and guaranteed to contain insignificant levels of heavy metals, PCBs, pesticides, and other organic chemical contaminants.

The Vitamin E in ESSENTIAL FATS PLUS E includes all of the known tocotrienols and tocopherols derived from rice bran oil, and is included in the softgel capsules for antioxidant protection of the polyunsaturated oils both inside the softgel and inside the body.

A high-quality essential fatty acid formula is a foundational nutritional supplement that is part of a complete nutritional supplement program. Along with a multivitamin and a Vitamin C / antioxidant formula (like Ultimate Protector™ or PRO-C™), an essential fats formula is a starting-point for building a program uniquely designed to suit your individual requirements.

HPDI founder Dr. Hank Liers co-developed ESSENTIAL FATS PLUS Eas a next generation EFA formula with his colleague Dr. Brian Cabin, a leader in holistic health care. This formula is the leading edge in a series of exclusive formulas in the Hank & Brian's™ label. We proudly offer ESSENTIAL FATS PLUS E as a very special “top of the line” formula that produces exceptional results. It is among our most popular formulas because it effectively provides essential fats necessary for excellent health.

ESSENTIAL FATS PLUS E is a highly advanced essential fatty acid formula offering special benefits:

  • UNIQUE COMBINATION — Essential Fats (EPA, DHA, GLA) plus Vitamin E. This unique formula offers more than one type of Vitamin E (not just d-alpha-tocopherol) and balanced essential fats.
  • BALANCED ESSENTIAL FATS— Many EFA supplements contain only omega-3s, but for optimal function the body requires a balance of omega-3 and omega-6 essential fats. in addition, our special formula provides a 4-to-1 ratio of EPA to GLA in order to achieve a balance you need for optimal health.
  • FULL-SPECTRUM VITAMIN E — Tocotrienols and tocopherols in this formula are natural vitamin E substances derived from oryza rice bran oil and protect polyunsatured EFAs against free-radical damage both in the capsule and in your body. Many Vitamin E supplements contain only d-alpha tocopherol, which is only a single component of the full-spectrum Vitamin E in this formula. Try an essential fats formula with full-spectrum Vitamin E and see the difference for yourself!
  • ULTRAPURE — Molecularly distilled oils of extremely high-purity containing no PCBs, heavy metals, or oxidized contaminants. Free of excipients, additives, and common food allergens!
  • FOUNDATIONAL SUPPLEMENT — Designed as part of a foundational supplement regimen. Providing essential fats and Vitamin E complex for foundational nutrition, ESSENTIAL FATS PLUS E works best with other foundational formulas, including our multivitamin formulas (e.g., Mighty Multi-Vite!™), Vitamin C / Antioxidant formulas (especially Ultimate Protector™ or PRO-C™), and REJUVENATE!™ superfoods that together form a complete foundational supplement program. A high-quality essential fatty acid formula is foundational to a regimen that meets your individual needs.

    Please read "Why You Need Foundational Supplements" to learn more about HPDI’s philosophy of supplementation, and to understand the role played by foundational nutrients in creating and maintaining optimal health.


Omega-3 and omega-6 fatty acids are known to play important roles in the formation of prostaglandins. The prostaglandins are important cellular regulators controlling inflammatory processes and pain in the body. Fish oils may be useful adjuncts in protocols for 1) Cardiovascular health, 2) Blood pressure, 3) inflammation, 4) skin health, 5) Balancing blood sugar, 6) Sadness, and 7) Kidney health. Research indicates that in a balanced formula there are synergistic effects between EPA, DHA, and GLA. For example, it is known that EPA inhibits the conversion of GLA into pro-inflammatory (and pain-causing) arachidonic acid.

Because these fatty acids have many double bonds that are prone to oxidation, Vitamin E is included in the forms of mixed tocotrienols and tocopherols. In addition, these forms of Vitamin E have been shown to 1) Enhance blood flow, 2) Protect serum lipids from oxidation (including LDL and HDL), 3) Reduce carotid stenosis (narrowing) and, 5) Trap harmful nitrogenous radicals, 6) Act as anti-proliferative agents, and 7) Provide powerful oxidative defense for the skin. 

COMPOSITION: Two softgel capsules provides the following percentages of the Daily Value:

EPA (Eicosapentaenoic Acid 20:5 omega 3)
   (from 668 mg of purified fish oils)
120 mg *
DHA (docosahexaenoic Acid 22:6 omega 3)
  (from 668 mg of purified fish oils)
80 mg *
GLA (Gamma Linolenic Acid 18:3 omega 6)
   (from 150 mg of cold pressed borage seed oil)
30 mg *
Vitamin E (d-alpha-tocopherol) (from Oryza rice bran oil) 8 IU 27%
Mixed Tocotrienols (d-gamma, d-alpha, and d-delta)
   (from 60 mg of Oryza rice bran oil)
9.6 mg *

* No established Daily Value
† Daily Values based on a 2,000 calorie diet

DIRECTIONS: As a dietary supplement take six (6) capsules daily with food, or as directed by a health care professional.

INGREDIENTS: ESSENTIAL FATS PLUS E only contains the highest-quality molecularly distilled fish oils, cold-pressed borage seed oil, Oryza rice bran oil (from Japonica species), gelatin (capsule), glycerin (capsule), and water (capsule).

ESSENTIAL FATS PLUS E does not contain wheat, rye, oats, corn, barley, gluten, soy, egg, dairy, GMOs, sugar, yeast, sulfates, chlorides, phosphates, wax, preservatives, colorings, or artificial flavorings.


These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.