• HOMOCYSTEINE CALM is formulated to lower homocysteine levels. It contains the active coenzyme forms of folate as folinic acid, Vitamin B12 as methylcobalamin, and Vitamin B6 as pyridoxal-5'-phosphate. Also included is trimethylglycine (anhydrous betaine), an important methyl donor. Homocysteine Calm contains the purest forms available of all ingredients and is suitable for hypersensitive individuals. It contains no magnesium stearate.
• Homocysteine is a sulfur containing amino acid that is formed in the body from the essential amino acid methionine. High levels of homocysteine in the blood are known to cause the formation of plaques in the blood vessels leading to arteriosclerosis, the major cause of loss of life.
• According to Dr. Kilmer S. McCully, acclaimed author of The Homocysteine Revolution, homocysteine interferes with the way cells use oxygen, resulting in a build-up of damaging free radicals. These reactive chemical forms can oxidize low-density lipoproteins (LDL), producing oxycholesterols and oxidized fats and proteins within developing plaques.
• Homocysteine also stimulates growth of smooth muscle cells, causing deposition of extracellular matrix and collagen, which causes a thickening and hardening of artery walls. It has been shown that homocysteine can be reconverted to methionine by the B vitamins of folates and methylcobalamin (a coenzyme form of Vitamin B12). Working together these two vitamins cause a methyl group from the methylcobalamin to be transferred to homocysteine converting it in the process back to methionine.
• Another way that homocysteine levels can be reduced is by using a form of Vitamin B6 known as pyridoxal-5'-phosphate. Pyridoxal-5'-phosphate causes homocysteine to be converted into a substance called cystathione that itself is converted to the amino acid cysteine. Cysteine is used in the body in the production of the extremely protective tripeptide glutathione. A supplement containing reasonable amounts of these B vitamins can lower homocysteine levels and reduce the risk of arteriosclerosis.
• There is an alternative pathway for conversion of homocysteine to methionine involving betaine (also known as trimethylglycine). This methyl donor function of betaine has a supplementary action in lowering elevated homocysteine levels both in chronic renal failure and also in patients with homocystinuria. Homocysteine Calm therefore includes anhydrous betaine.
• Recent research on homocysteine also has implicated abnormal homocysteine metabolism in a wide range of other important disease processes, including developmental birth defects, neurodegenerative diseases such as Alzheimer's disease, autoimmune diseases (e.g., rheumatoid arthritis), hormonal imbalances, renal failure, cancer, and various degenerative diseases of aging.
These products are not intended to diagnose, treat, cure, or prevent any disease.